Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 5, Pages 1055-1062Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00938
Keywords
-
Funding
- DFG [GRK 2158]
- Manchot Foundation
- Natural Science Foundation of Jiangsu Province, China [BK20181063]
- NSFC [21606097]
- Six Talent Peaks Project in Jiangsu Province [SWYY-026]
Ask authors/readers for more resources
Ten new sesquiterpenoid derivatives, rhinomilisins A-J (1-10), along with six known analogues (11-16), were isolated from the mangrove-derived endophytic fungus Rhinocladiella similis. The structures of the new compounds were elucidated by their NMR and MS data, while the absolute configuration of 3 and 6 was determined by X-ray crystallographic analysis and Mosher's method, respectively. All isolated compounds (1-16) were evaluated for their cytotoxicity against the mouse lymphoma cell line L5178Y, and compounds 1, 7, and 15 showed moderate activity with IC50 values of 5.0, 8.7, and 24.4 mu M, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available