Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1182, Issue -, Pages 63-71Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2019.01.029
Keywords
Azo-azomethine; Metal complexes; Anticancer activity; Antioxidant properties; Electrochemical
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Funding
- Unit of Coordination of Scientific Research Projects, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey [2015/1-16YLS]
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Co(II), Cu(II) and Zn(II) complexes derived from azo-azomethine compounds were synthesized and characterized by a combination of magnetic susceptibility, elemental analyses, FTIR and UV-Visible spectroscopies. The characterized complexes were found to be mononuclear and the chelation of the ligands to the metal ions occurs through phenolic oxygen and nitrogen atoms of the azomethine group of the ligands. Solid state structure of 5 was determined by single crystal X-ray diffraction studies. The electrochemical and photoluminescence properties of the synthesized compounds were also studied. In order to evaluate the ability of the compounds to inhibit cell proliferation, we treated MCF7 (breast cancer), PC3 (prostate cancer) and H2126 (lung cancer) cells with different concentrations of Co(II), Cu(II) and Zn(II) complexes bearing the azo-azomethine ligands. When nine Co(II), Cu(II) and Zn(II) complexes were assessed within themselves, our results highlighted that three compounds (8, 9 and 10) had the best inhibitory activity on all cell lines. (C) 2019 Elsevier B.V. All rights reserved.
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