Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 62, Issue 9, Pages 4500-4525Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.9b00056
Keywords
-
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [337381]
- Natural Sciences and Engineering Research Council of Canada (NSERC) [337381]
- Shastri Indo-Canadian Institute, India
Ask authors/readers for more resources
Peptide mimicry employing a combination of aza-amino acyl proline and indolizidinone residues has been used to develop allosteric modulators of the prostaglandin F2a receptor. The systematic study of the N-terminal phenylacetyl moiety and the conformation and side chain functions of the central turn dipeptide residue has demonstrated the sensitive relationships between modulator activity and topology. Examination of aza-Gly-Pro and aza-Phe-Pro analogs 2a and 2b in a murine preterm labor model featuring treatment with lipopolysaccharide demonstrated their capacity to extend significantly (>20 h) the average time of delivery offering new prototypes for delaying premature birth.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available