Journal
JOURNAL OF MEDICAL MICROBIOLOGY
Volume 68, Issue 6, Pages 957-960Publisher
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.000979
Keywords
qacA/B-positive methicillin-resistant Staphylococcus aureus; olanexidine; fast-acting bactericidal activity
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Funding
- Otsuka Pharmaceutical Factory, Inc.
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The qacA/B gene is one of the major determinants of resistance to antiseptics in methicillin-resistant Staphylococcus aureus (MRSA). Here, we compared the fast-acting bactericidal activity of skin antiseptics, including olanexidine gluconate (OLG), a new biguanide antiseptic agent introduced in Japan, against clinical qacA/B-positive MRSA strains by determination of minimum bactericidal concentration and time-kill assay. Our findings provide, for the first time, data indicating that the fast-acting bactericidal activity of OLG against qacA/B-positive MRSA is higher than that of chlorhexidine gluconate, even though both are biguanide antiseptics.
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