Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 34, Issue 4, Pages 653-659Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14767058.2019.1611771
Keywords
Asthma; meta-analysis; pregnancy; vitamin D; wheeze
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Funding
- National Key Research and Development Program of China [2016YFC1303903]
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This study based on ten articles suggests that mothers who supplement with vitamin D during pregnancy may reduce the risk of asthma or wheeze in infants compared to those who do not.
Aims: To summarize the relationship between vitamin D and infant asthma or wheeze. Materials and methods: We used PubMed and Embase to search articles through July 2017 with selection criteria for relevant studies. Random-effect models were used to pool the results of included studies. Results: Ten articles with 14 independent reports of 2073 incident cases of asthma and 1875 cases of wheeze among 23 030 pairs of mother and child were included in our meta-analysis. Compared to those who did not take vitamin D, the mothers who had vitamin D supplementation during pregnancy stage could reduce the risk of asthma or wheeze in infants. The combined odds ratio of infant wheeze was 0.65 (95% CI = 0.54-0.79) and asthma was 0.78 (95% CI = 0.69-0.89). The results almost did not change in the subgroup analyses. Conclusions: It suggests that increasing maternal vitamin D intake during pregnancy might have a protective effect on suffering from wheeze and asthma for children.
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