Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 301, Issue -, Pages 73-79Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2019.01.015
Keywords
Coil combination; C-13; Hyperpolarized; Pyruvate; DNP
Funding
- NIH [R01CA183071, P41EB013598]
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Effective coil combination methods for human hyperpolarized C-13 spectroscopy multi-channel data had been relatively unexplored. This study implemented and tested several coil combination methods, including (1) the sum-of-squares (SOS), (2) singular value decomposition (SVD), (3) Roemer method by using reference peak area as a sensitivity map (RefPeak), and (4) Roemer method by using ESPIRiT-derived sensitivity map (ESPIRiT). These methods were evaluated by numerical simulation, thermal phantom experiments, and human cancer patient studies. Overall, the SVD, RefPeak, and ESPIRiT methods demonstrated better accuracy and robustness than the SOS method. Extracting complex pyruvate signal provides an easy and excellent approximation of the coil sensitivity map while maintaining valuable phase information of the coil-combined data. (C) 2019 Elsevier Inc. All rights reserved.
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