Journal
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Volume 42, Issue 9-10, Pages 227-237Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10826076.2019.1585614
Keywords
Bioaccumulation; drug discovery; micellar liquid chromatography; micellar thin layer chromatography; toxicity; drug-membrane interactions
Funding
- Medical University of Lodz [503/3-016-03/503-31-001]
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A review of applications of micellar liquid chromatography (MLC) with special stress upon micellar thin layer chromatography (MTLC) in drug discovery is given. MLC and MTLC are presented as valuable sources of information on the physicochemical properties (mainly lipophilicity) of solutes and as tools to predict their biological activity: interactions with biomembranes, blood-brain barrier permeability, plasma protein binding, volume of distribution, gastric, ocular and skin absorption, environmental toxicity and bioaccumulation. The results of modeling based on the MLC/MTLC descriptors are correlated with those obtained by other in vitro, in vivo or in silico techniques used to study bioavailability. The future prospects of MTLC application in drug discovery and safety assessments of environmentally hazardous compounds are discussed. [GRAPHICS] .
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