Journal
JOURNAL OF LIPID RESEARCH
Volume 60, Issue 7, Pages 1190-1198Publisher
ELSEVIER
DOI: 10.1194/jlr.M089664
Keywords
cholesterol; disease progression; metabolism
Categories
Funding
- National Institute of Neurological Disorders and Stroke Grant [1R21NS098169]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR001412]
- National Institutes of Health
- National Multiple Sclerosis Society
- National Science Foundation
- Department of Defense
- EMD Serono
- Biogen Idec
- Teva Neuroscience
- Cyberonics
- Novartis
- Acorda
- Jog for the Jake Foundation
- National Institute of Neurological Diseases and Stroke
- Genzyme-Sanofi
- Mapi-Pharma
- PRAH
- Protembis
- Celgene
- V-WAVE Medica
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The purpose of this work was to investigate whether changes in oxysterol and apolipoprotein levels over 5 years are associated with disease course and disability progression in multiple sclerosis (MS). This study included 139 subjects [39 healthy controls (HCs), 61 relapsing-remitting MS (RR-MS) patients, and 39 progressive MS (P-MS) patients]. Oxysterols [24-hydroxycholesterol (24HC), 25-hydroxycholesterol (25HC), 27-hydroxycholesterol (27HC), 7 alpha-hydroxycholesterol (7 alpha HC), and 7-ketocholesterol (7KC)] were measured at baseline and 5 years using a novel mass spectrometric method, and apolipoproteins were measured using immunoturbidometric diagnostic kits. Levels of 24HC (P = 0.004), 25HC (P = 0.029), and 27HC (P = 0.026) increased in P-MS patients. 7KC (P = 0.047) and 7 alpha HC (P = 0.001) levels decreased in RR-MS patients, and there were no changes in any oxysterols in HCs. In MS patients, ApoC-II (all P <= 0.01) and ApoE (all P <= 0.01) changes were positively associated with all oxysterol levels. Increases in 24HC (P = 0.038) and ApoB (P = 0.038) and decreases in 7KC (P = 0.020) were observed in RR-MS patients who converted to secondary P-MS (SP-MS) at follow-up and in SP-MS patients compared with RR-MS patients. Oxysterols and their associations with apolipoproteins differed between MS patients and HCs over 5 years. Oxysterol and apolipoprotein changes were associated with conversion to SP-MS.
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