Journal
JOURNAL OF LIGHTWAVE TECHNOLOGY
Volume 37, Issue 11, Pages 2756-2761Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JLT.2018.2878762
Keywords
Aptamer; fiber-optic biosensor; tapered fiber interferometer; thrombin detection
Funding
- Natural Science Young Foundation of Shanxi Province [201601D021024]
- Open Fund of Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications (Jinan University)
- National Natural Science Foundation for Excellent Youth Foundation of China [61722505]
- Key Program of Guangdong Natural Science Foundation [2018B030311006]
- Key Collaborative Innovation of Guangzhou Natural Science Foundation [201604030084]
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Aptamer biosensor for label-free thrombin detection based on a tapered fiber-optic interferometer has been proposed and demonstrated. The biosensor probe can be easily fabricated by tapering a commercial double-cladding fiber down to 5 mu m in diameter and it provides a high refractive index sensitivity of 1660 nm/RIU. The changes are determined by tracing the wavelength shift of the dip in the transmission spectrum with variable surrounding refractive index. With the help of the surface functionalization of thrombin-binding aptamers, the proposed fiber-optic biosensor proves its capability in label-free detection of thrombin with a lowest detectable concentration of 0.1 mu m, together with high specificity in various concentrations of pure and mixed thrombin solutions.
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