Journal
JOURNAL OF LIGHTWAVE TECHNOLOGY
Volume 37, Issue 11, Pages 2616-2622Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JLT.2018.2889324
Keywords
Biosensors; evanescent wave; interfacial sensitization; optical microfiber
Funding
- National Natural Science Foundation of China [U1701268, 51773084]
- Fundamental Research Funds for the Central Universities [21617420]
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Sensitivity is an important parameter to characterize the performance of sensors. Interfacial modification and functionalization is an effective strategy to improve the sensitivity of optical biosensors. This paper reports our recent development on interface sensitized fiber optic biosensors for the detection of ultra-low concentration of biological targets. We employ microfiber mode interferometer as transducer to sense the molecular binding interaction induced surrounding refractive index change. By modifying the microfiber surface to increase the assembling surface area and enhance the evanescent field energy density, ultra-low limit of detection of 1.65 x 10(-15) M and 6.82 x 10(-17) M, respectively, were realized for neurotransmitter.-amino-butyric acid and cellular cytochrome c.
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