Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 193, Issue -, Pages 25-30Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2019.01.007
Keywords
Complexation; H-1 NMR; HPLC-MS; DFT; Luteolin; Lead
Funding
- National Natural Science Foundation of China [31272510, 31871876]
- Science Foundation of Forestry Department of Shaanxi Province [2017-01]
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The interactions of (CH3COO)(2)Pb center dot 3H(2)O (lead acetate trihydrate) with luteolin, 5,7,3',4'-tetrahydroxyflavone, were investigated in methanol solution. The spectroscopy (UV-Vis, FT-IR, HPLC-MS, H-1 NMR) and elemental analysis were adopted to assess the interaction of luteolin and Pb(II). The results show that luteolin reacts with Pb(II) through the chelating sites of 4-carbonyl and 5-hydroxy in two luteolin molecules. The structures, energies, CDA (charge decomposition analysis) and orbitals analysis of the ligand and complex have been analyzed according to quantum-chemical calculation, which is further proofed that luteolin molecule can effectively chelate Pb(II) by 5-hydroxyl-4-oxo chelating site. It is speculated that luteolin has a high potential of becoming a health care product to eliminate lead cation in the future.
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