Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 220, Issue 6, Pages 1001-1007Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiz237
Keywords
human herpesvirus 6; allogeneic hematopoietic stem cell transplantation; digital polymerase chain reaction; T cells; CD134
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Funding
- JSPS KAKENHI [JP17K09961]
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Background. Human herpesvirus 6 (HHV-6) causes life-threatening central nervous system disorders after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recent studies implicated CD134 as a specific receptor of HHV-6B and demonstrated that its expression levels in CD4-positive T cells after allo-HSCT could be related to the reactivation of HHV-6. We prospectively evaluated the relationship between HHV-6 reactivation and CD134(+) T cells in the recipients of allo-HSCT. Methods. HHV-6 viral load in plasma was quantitatively measured weekly after allo-HSCT by digital polymerase chain reaction in 34 patients. The ratio of CD134 in CD4(+) T cells (CD134/CD4 ratio) was serially measured by flow cytometry before and after transplantation. Results. HHV-6 reactivation was detected in 23 patients (68%). The CD134/CD4 ratio before conditioning was significantly higher in patients with HHV-6 reactivation than in those without (median, 3.8% vs 1.5%, P < .01). In multivariate analysis, a higher CD134/CD4 ratio before conditioning was significantly associated with the incidence of HHV-6 reactivation (odds ratio, 10.5 [95% confidence interval, 1.3-85.1], P = .03). Conclusions. A higher CD134/CD4 ratio before conditioning was associated with a higher risk of HHV-6 reactivation, suggesting that the rate may be a promising marker for predicting HHV-6 reactivation after allo-HSCT.
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