Journal
JOURNAL OF HOSPITAL INFECTION
Volume 103, Issue 1, Pages 85-91Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jhin.2019.04.007
Keywords
Clostridioides difficile; Attributable mortality; Epidemiology; Length of stay
Funding
- Vanier Canada Graduate Scholarship
- Alberta Innovates-Health Solutions Graduate Studentship
- University of Calgary's Eyes High Doctoral Recruitment award
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In a population-based, five-year retrospective cohort study of 5304 adult patients with hospital-acquired Clostridioides difficile infection across Alberta (N=101 hospitals), 30-day all-cause and attributable mortality were 12.2% and 4.5%, respectively. Patients >75 years of age had the highest odds of attributable mortality (odds ratio (OR) 9.34, 95% confidence interval (CI) 2.92-29.83) and largest difference in mean length of stay (11.7 days, 95% CI 8.2-15.2). A novel finding was that elevated white blood cell count at admission was associated with reduced attributable mortality (OR 0.67, 95% CI 0.50-0.90) which deserves further study. Advancing age was incrementally and significantly associated with all outcomes. (C) 2019 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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