Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 216, Issue 5, Pages 1061-1070Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20181522
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Funding
- US National Institutes of Health [R01-CA169416]
- Feldstein Foundation
- Starr Cancer Consortium
- Ministerio de Economia y Competitividad
- Ramon y Cajal Program
- Atresmedia-Fundacion AXA
- La Caixa Foundation [100010434, LCF/BQ/ES17/11600007]
- Fundacion Cientifica Asociacion Espanola Contra el Cancer
- Fundacion de Investigacion Oncologica
- Ministerio de Economia y Competitividad-Red de Excelencia en Investigacion e Innovacion en Exosomas
- Ramon Areces Foundation
- Comunidad Autonoma de Madrid
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Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting. We have characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stage III melanoma patients obtained after lymphadenectomy. Proteomic analysis showed that seroma-derived exosomes are enriched in proteins resembling melanoma progression. In addition, we found that the BRAF(V600E) mutation can be detected in ES-derived extracellular vesicles and its detection correlated with patients at risk of relapse.
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