Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 216, Issue 6, Pages 1234-1243Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20181739
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Funding
- Georg-Speyer-Haus
- LOEWE Center Frankfurt Cancer Institute - Hessen State Ministry for Higher Education, Research and the Arts [III L 5 - 519/03/03.001 - (0015)]
- Deutsche Forschungsgemeinschaft [FOR2438: Gr1916/11-1, SFB 815, SFB 1177, SFB 1292]
- German Federal Ministry of Health of the State of Hessen
- Ministry of Higher Education Research and the Arts of the State of Hessen
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A link between chronic inflammation and development of tumors is well established. Moreover, it has become evident that tumorigenesis is not a cell autonomous disease, and an inflammatory microenvironment is a prerequisite of basically all tumors, including those that emerge in the absence of overt inflammation. This knowledge has led to the development of anti-inflammatory concepts to treat and prevent cancer. In contrast, immunotherapies, in particular checkpoint inhibitors, representing the most significant progress in the therapy of several malignancies depend on the presence of a pro-inflammatory hot environment. Here, we discuss pro- and anti-inflammatory concepts for the treatment of cancer.
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