Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 38, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13046-019-1214-z
Keywords
Metabolic reprogramming; Chemo-resistance; Radio-resistance; TME
Categories
Funding
- National Natural Science Foundation of China [81872281, 81472595]
- Natural Science Foundation of Hunan Province [2018JJ1013, 2017JJ3190, 2016JJ4059]
- Research Project of the Health and Family Planning Commission of Hunan Province [B20180400, B20180582, B2016056]
- Changsha Science and Technology Board [kq1706045, kq1706043]
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Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and radiation. When the glucose metabolism of cancer is rewiring, the characters of cancer will also occur corresponding changes to regulate the chemo- and radio-resistance of cancer. The procedure is involved in the alteration of many activities, such as the aberrant DNA repairing, enhanced autophagy, oxygen-deficient environment, and increasing exosomes secretions, etc. Targeting altered metabolic pathways related with the glucose metabolism has become a promising anti-cancer strategy. This review summarizes recent progress in our understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment.
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