Journal
JOURNAL OF CYSTIC FIBROSIS
Volume 18, Issue 6, Pages 804-807Publisher
ELSEVIER
DOI: 10.1016/j.jcf.2019.04.005
Keywords
Achromobacter; nrdA; MLST; Identification; Resistance; Cystic fibrosis; ST 137
Categories
Funding
- Vaincre la mucoviscidose (Paris, France) [RF20150501371]
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We previously reported the distribution of Achromobacter spp. (species and Sequence Types (ST)) in our French Cystic Fibrosis (CF) centre. In the present study we collected 109 Achromobacter isolates (1/patient) from 9 other French CF Centres for species identification, antimicrobial susceptibility testings and Multilocus-Sequence-Typing (MLST) analysis. Ten species were detected, A. xylosoxidans being the most predominant one (73.4% of the isolates). Piperacillin-tazobactam, ceftazidime, imipenem, meropenem and ciprofioxacin were respectively active against 88, 70, 79, 72 and 23% of the isolates. Among the 79 A. xylosoxidans isolates, 46 STs were detected. Interestingly, ST 137, recovered in 4 centres (5 patients), was previously detected in our centre (2 patients). The strains from the 7 patients belonged to the same pulsotype (pulsed-field-gel-electrophoresis analysis) and harboured acquired resistance to meropenem, ceftazidime, ciprofioxacin, and except for 2 isolates, to imipenem and piperacillin-tazobactam. This is the first description in France of a circulating multiresistant A. xylosoxidans strain. (C) 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
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