Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 543, Issue -, Pages 114-121Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2019.02.043
Keywords
Contact lenses; ZnO nanoparticles; Chitosan; Gallic acid; Sonochemistry; Antibacterial coating
Categories
Funding
- European Community [H2020-720851]
- Spanish National Project HybridNanoCoat [MAT2015-67648-R]
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Contact lenses (CL) provide visual correction but their use may also induce several adverse effects causative of discomfort and conditions that lead to stop or discontinue their use. Discomfort is mainly caused by insufficient wetting, impairment of the antioxidant defence system and eye infections. The current work reports on a single step sonochemical coating of CL with ZnO nanoparticles (NPs), chitosan (CS) and gallic acid (GA). GA and CS are expected to improve the comfort of CL by imparting respectively antioxidant properties and enhanced wettability, while their combination with ZnO NPs provides the CL with antimicrobial properties. The ternary composite coating presents high antibacterial efficiency (>4.5 logs reduction) against S. aureus causative of CL-related conditions, and maintains good biocompatibility (>72%) with human cell lines. The obtained multi-functionality on the CL did not affect their geometry and refractive properties. (C) 2019 The Authors. Published by Elsevier Inc.
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