Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 129, Issue 6, Pages 2480-2484Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI125534
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Funding
- Intramural Research Program of the NIDA, NIH
- Canadian Institutes of Health Research (CIHR) [FRN 152478]
- NATIONAL INSTITUTE ON DRUG ABUSE [ZIADA000597] Funding Source: NIH RePORTER
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Opioid use disorder is associated with the emergence of persistent negative emotional states during drug abstinence that drive compulsive drug taking and seeking. Functional magnetic resonance imaging (fMRI) in rats identified neurocircuits that were activated by stimuli that were previously paired with heroin withdrawal. The activation of amygdala and hypothalamic circuits was related to the degree of heroin dependence, supporting the significance of conditioned negative affect in sustaining compulsive-like heroin seeking and taking and providing neurobiological insights into the drivers of the current opioid crisis.
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