Journal
JOURNAL OF CLINICAL EPIDEMIOLOGY
Volume 115, Issue -, Pages 1-13Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinepi.2019.04.018
Keywords
Network meta-analysis; Decision-making; Systematic reviews; Summary of findings; GRADE; Certainty of evidence
Funding
- endowed Michael Gent Chair in Healthcare Research
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Objectives: The aim of the study was to develop a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) summary of findings (SoF) table format that displays the critical information from a network meta-analysis (NMA). Study Design and Setting: We applied a user experience model for data analysis based on four rounds of semistructured interviews. Results: We interviewed 32 stakeholders who conduct or use MA. Four rounds of interviews produced six candidate NMA-SoF tables. Users found a final NMA-SoF table that included the following components highly acceptable: (1) details of the clinical question (PICO), (2) a plot depicting network geometry, (3) relative and absolute effect estimates, (4) certainty of evidence, (5) ranking of treatments, and (6) interpretation of findings. Conclusion: Using stakeholder feedback, we developed a new GRADE NMA-SoF table that includes the relevant components that facilitate understanding NMA findings and health decision-making. (C) 2019 Published by Elsevier Inc.
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