Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1601, Issue -, Pages 340-349Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2019.04.040
Keywords
Chiral ionic liquids; Capillary electrophoresis; Enantioseparation; Synergistic system; Molecular docking
Funding
- Project of National Natural Science Foundation of China [81373378]
- Natural Science Foundation of Jiangsu Province [BK20150697]
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In this study, three functionalized chiral ionic liquids (CILs) derived from L-valinol, L-prolinol and L-phenylalaninol, namely N,N,N-trimethyl-L-valinol-bis(trifluoromethanesulfon)imide ([TMLV](+)[Tf2N](-), CIL1), N,N-dimethyl-L-prolinol-bis(trifluoromethanesulfon)imide ([DMLP](+)[Tf2N](-), CIL2) and N,N,N-trimethyl-L-phenylalaninol-bis(trifluoromethanesulfon)imide ([TMLP](+)[Tf2N](-), CIL3), were synthesized and subsequently utilized for enantiomeric separation in capillary electrophoresis (CE) with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as chiral selector for the first time. Compared with traditional single HP-beta-CD separation system, the synergistic system exhibited substantially improved separations of six tested drugs. Using the CIL1/HP-beta-CD as a model system, the influence of crucial parameters including the type and proportion of organic modifier, CILs concentration, HP-beta-CD concentration and buffer pH was investigated in detail. Additionally, molecular modeling with AutoDock was applied to elucidate the enhanced enantioselectivity in the presence of CILs, which has certain guiding value in predicting the migration order of the enantiomers and studying the interactions important for the chiral recognition. (C) 2019 Elsevier B.V. All rights reserved.
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