Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 12, Pages 21485-21492Publisher
WILEY
DOI: 10.1002/jcp.28895
Keywords
arthritis; autophagy; cancer; cardiac diseases; renal diseases; senescence
Categories
Funding
- Deanship of Scientific Research, King Faisal University [186174]
- Deanship of Scientific Research at King Faisal University [186174]
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Senescence and autophagy play important roles in homeostasis. Cellular senescence and autophagy commonly cause several degenerative processes, including oxidative stress, DNA damage, telomere shortening, and oncogenic stress; hence, both events are known to be interrelated. Autophagy is well known for its disruptive effect on human diseases, and it is currently proposed to have a direct effect on triggering senescence and quiescence. However, it is yet to be proven whether autophagy has a positive or negative impact on senescence. It is known that elevated levels of autophagy induce cell death, whereas inadequate autophagy can trigger cellular senescence. Both have important roles in human diseases such as aging, renal degeneration, neurodegenerative disorders, and cancer. Therefore, this review aims to highlight the relevance of senescence and autophagy in selected human ailments through a summary of recent findings on the connection and effects of autophagy and senescence in these diseases.
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