Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 23, Issue 6, Pages 3784-3794Publisher
WILEY
DOI: 10.1111/jcmm.14292
Keywords
biomaterials; induced pluripotent stem cells; iPSCs; iPS-skeletal muscle; personalized medicine; regenerative medicine; scaffold; tissue engineering; volumetric muscle loss
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Funding
- 'Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III - FEDER Funds' [PI15/00484, PI18/00151]
- Ministerio de Educacion, Cultura y Deporte [FPU16/03895]
- Instituto de Investigacion Sanitaria Hospital 12 de Octubre i+12
- Instituto de Salud Carlos III [CP16/00046]
- FEDER funds
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Both volumetric muscle loss (VML) and muscle degenerative diseases lead to an important decrease in skeletal muscle mass, condition that nowadays lacks an optimal treatment. This issue has driven towards an increasing interest in new strategies in tissue engineering, an emerging field that can offer very promising approaches. In addition, the discovery of induced pluripotent stem cells (iPSCs) has completely revolutionized the actual view of personalized medicine, and their utilization in skeletal muscle tissue engineering could, undoubtedly, add myriad benefits. In this review, we want to provide a general vision of the basic aspects to consider when engineering skeletal muscle tissue using iPSCs. Specifically, we will focus on the three main pillars of tissue engineering: the scaffold designing, the selection of the ideal cell source and the addition of factors that can enhance the resemblance with the native tissue.
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