Journal
JOURNAL OF CELL SCIENCE
Volume 132, Issue 7, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.223826
Keywords
Survivin; BIRC5; Cancer; Mitosis; Apoptosis
Categories
Funding
- National Institutes of Health [P01 CA140043, R35 CA220446]
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Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. In this Cell Science at a Glance article and accompanying poster, we summarise our knowledge of survivin 21 years on from its initial discovery. We describe the structure, expression and function of survivin, highlight its interactome and conclude by describing anti-survivin strategies being trialled.
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