Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 145, Issue 7, Pages 1665-1679Publisher
SPRINGER
DOI: 10.1007/s00432-019-02940-0
Keywords
microRNAs; Phytochemicals; Plant-derived food; Cancer; Carcinogenesis
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Funding
- Scientific Grant Agency of the Ministry of Education of the Slovak Republic [VEGA 1/0136/19, 1/0124/17]
- Slovak Research and Development Agency [APVV-16-0021]
- Operational Programme Research and Innovation - ERDF [ITMS: 26220120036, ITMS: 26220220113]
- Government of Russian Federation [08-08]
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PurposePhytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis.ResultsThis comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research.ConclusionsSignificant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.
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