Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 33, Issue 9, Pages 1265-1276Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328218816526
Keywords
Hydrogels; wet wound dressings; alginate; curcumin; t-resveratrol
Funding
- National Institutes of Health [GM126831, AR073822]
- University of Nebraska-Lincoln
- Nebraska Tobacco Settlement Biomedical Research Enhancement Funds
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Traditional wound dressings are not effective enough to regulate the moisture content and remove excessive exudate from the environment. Wet wound dressings formed from hydrogels such as alginate are widely used in clinical practice for treatment of skin disorders. Here, we functionalize alginate dressings with natural antioxidants such as curcumin and t-resveratrol to render them both anti-inflammatory and antibacterial. The hydrogel maintains excellent mechanical properties and oxygen permeability over time. The release rate of the compounds from the hydrogels is assessed and their impact on bacterial and cellular growth is evaluated. The antioxidant compounds act as bactericidal agents and improve cell viability. The optimal concentration of active compounds in the engineered alginate-based dressings is determined.
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