Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 22, Issue 5, Pages 452-463Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2019.1585820
Keywords
Pancreatic cancer; coptisine; PANC-1 cell
Funding
- Youth teacher project [2017-JYB-JS056]
- National Natural Science Foundation of China [ZYBZH-Y-HUB-20]
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The effects of coptisine against advanced stage of human pancreatic carcinoma PANC-1 cells was investigated in vitro. Coptisine (25-150 mu M) treatment for 48 h caused dose-dependent cell growth inhibition by using CCK-8 assay. Additionally, coptisine was found to inhibit PANC-1 cells metastasis by the wound healing assay. Flow cytometry data indicated that coptisine (25-100 mu M) exhibited dose-dependent G1 phase arrest and moderate reduction of S phase. Coptisine was also found to inhibit ERK phosphorylation and total ERK levels. Our research suggested that coptisine would be a potential therapeutic drug for the treatment of pancreatic cancer. [GRAPHICS] .
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