Journal
JOURNAL OF APPLIED MICROBIOLOGY
Volume 127, Issue 5, Pages 1282-1290Publisher
WILEY
DOI: 10.1111/jam.14271
Keywords
antimicrobial; chalcones; flavanones; flavones; flavonoids
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The emergence of drug-resistant microbes left us with a great need for new antimicrobial agents. Flavonoids, with their wide range of biological activities, are good candidates in this respect. Although naturally occurring flavonoids are the most studied ones, semi-synthetic or synthetic flavonoids have proven to have great potential, inhibiting and even killing microbes at concentrations below 1 mu g ml(-1). The substitution pattern of these flavonoids often includes hydroxy groups, halogens or other heteroatomic rings, such as pyridine, piperidine or 1,3-dithiolium cations. However, the great variety in substituents makes it difficult to draw any definitive conclusion regarding their structure-activity relationship.
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