Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 67, Issue 22, Pages 6190-6201Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b01436
Keywords
Alzheimer's diseases; postsynaptic density; gut microbiota; Lactococcus; SCFAs
Funding
- National Key Research and Development Program of China [2016YFD0400601]
- National Natural Science Foundation of China [81871118, 81803231]
- China postdoctoral science foundation [2018T111104, 2016M602867]
- Key Research and Development Program of Shaanxi [2018NY-100]
- Fundamental research funds for the central universities [2452017141]
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Sesamol, an antioxidant lignan from sesame oil, possesses neuroprotective bioactivities. The present work was aimed to elucidate the systemic protective effects of sesamol on cognitive deficits and to determine the possible link between gut and brain. Wildtype and ApoE(-/-) mice were treated with a high-fat diet and sesamol (0.05%, w/v, in drinking water) for 10 weeks. Behavioral tests including Morris-water maze, Y-maze, and elevated plus maze tests indicated that sesamol could only improve cognitive deficits and anxiety behaviors in wildtype. Consistently, sesamol improved synapse ultrastructure and inhibited A beta accumulation in an ApoE-dependent manner. Moreover, sesamol prevented dietary-induced gut barrier damages and systemic inflammation. Sesamol also reshaped gut microbiome and improved the generation of microbial metabolites short-chain fatty acids. To summarize, this study revealed that the possible mechanism of neuroprotective effects of sesamol might be ApoE-dependent, and its beneficial effects on gut microbiota/metabolites could be translated into neurodegenerative diseases treatment.
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