Journal
JACC-CARDIOVASCULAR INTERVENTIONS
Volume 12, Issue 10, Pages 951-966Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jcin.2019.01.246
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Funding
- British Heart Foundation Clinical Research Training Fellowship [FS/16/74/32573]
- British Heart Foundation Centre for Research Excellence awards [RE/13/5/30177, RE/18/6/34217]
- MRC [MC_PC_12037] Funding Source: UKRI
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The goal of reperfusion therapies in ST-segment elevation myocardial infarction has evolved to include effective reperfusion of the microcirculation subtended by the culprit epicardial coronary artery. The index of microcirculatory resistance is measured using a pressure-and temperature-sensing coronary guidewire and quantifies microvascular dysfunction. The index of microcirculatory resistance is an independent predictor of microvascular obstruction, infarct size, and adverse clinical outcomes. It has the advantage of being immediately measurable in the catheterization laboratory, before the results of blood biomarkers or noninvasive imaging become available. This provides an opportunity for additional intervention that may alter outcomes. In this review, the authors provide a critical appraisal of the published research on the emerging role of the index of microcirculatory resistance as a tool to guide the stratification of patients for adjunctive therapeutic strategies in acute ST-segment elevation myocardial infarction. (J Am Coll Cardiol Intv 2019; 12: 951-66) (c) 2019 Published by Elsevier on behalf of the American College of Cardiology Foundation.
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