Journal
INTERNATIONAL MICROBIOLOGY
Volume 23, Issue 1, Pages 65-73Publisher
SPRINGER
DOI: 10.1007/s10123-019-00081-5
Keywords
Copper; Homeostasis; Ctr; P-type ATPase; Transcription factor
Categories
Funding
- Basque Government [IT599-13, S-PC13UN041]
Ask authors/readers for more resources
Copper is a metal ion that is required as a micronutrient for growth and proliferation. However, copper accumulation generates toxicity by multiple mechanisms, potentially leading to cell death. Due to its toxic nature at high concentrations, different chemical variants of copper have been extensively used as antifungal agents in agriculture and medicine. Most studies on copper homeostasis have been carried out in bacteria, yeast, and mammalian organisms. However, knowledge on filamentous fungi is less well documented. This review summarizes the knowledge gathered in the last few years about copper homeostasis in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans: The mechanism of action of copper, the uptake and detoxification systems, their regulation at the transcriptional level, and the role of copper homeostasis in fungal pathogenicity are presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available