Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 562, Issue -, Pages 241-248Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2019.03.027
Keywords
Eudragit (R) E PO; Mucoadhesion; Acrylated polymers; Slug mucosal irritation; Nasal drug delivery; Nose-to-brain delivery
Categories
Funding
- Ministry of Education and Science of the Republic of Tatarstan (Russia)
Ask authors/readers for more resources
Eudragit (R) E PO (EPO) is a terpolymer based on N, N-dimethylaminoethyl methacrylate with methylmethacrylate and butylmethacrylate, produced by Evonik Industries AG as a pharmaceutical excipient. In this work, EPO was chemically modified through reaction with acryloyl chloride. The successful modification of EPO was confirmed by FTIR, NMR-spectroscopy, elemental and thermal analysis. The degree of acrylation was determined by permanganatometric titration. The slug mucosal irritation test was used to demonstrate non-irritant nature of EPO and its acrylated derivatives (AEPO). The mucoadhesive properties of EPO and AEPO were evaluated using freshly excised sheep nasal mucosa and it was demonstrated that acrylated polymers facilitated greater retention of sodium fluorescein on mucosal surfaces compared to solution mixture of this dye solution with EPO as well as free dye.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available