Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 14, Issue -, Pages 3967-3982Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S206044
Keywords
Berberine; chemotherapy; radio-sensitization; Au MSNs; Janus; photothermal therapy
Funding
- National Key R&D Program of China [2017YFF0108600, 2017YFC0211900, 2016YFF0103800]
- National Natural Science Foundation of China [81771982, 61535010, 8160071152, 21803075]
- Key Research Program of the Chinese Academy of Sciences [KFZD-SW-210]
- Natural Science Foundation of Jiangsu Province [BK20181236]
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Background: The combination of chemotherapy with radiotherapy serves as a common therapeutic strategy in clinics. However, it is unsatisfactory due to its poor therapeutic efficiency and severe side-effects originating from chemotherapy-exerted systemic toxicity as well as radiation-induced injury. Purpose: Hence, Berberine (Ber), an isoquinolin alkaloid with low toxicity and protective effects against radiotherapy, was used as a novel chemotherapeutic agent for chemo-radiotherapy of liver cancer. Patients and methods: We preloaded Ber into folic acid targeting Janus gold mesoporous silica nanocarriers (FA-JGMSNs) for overcoming the poor bioavailability of Ber. Furthermore, FA-JGMSNs were not only employed as radiosensitizers for expanding radiotherapeutic effect, but also used as photothermal agents for supplementing chemo-radiotherapeutic effect by local photothermal therapy. Results: In vitro and in vivo experiemtal results demonstrated the highly efficient anti-tumor effect, good biosafety as well as the effective protection of normal tissue of this nanoplatform. Conclusion: Based on its superb performance, we believe our work provided a feasible strategy for triple-therapies of liver cancer.
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