Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 14, Issue -, Pages 3389-3401Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S198848
Keywords
nanocarrier; drug release; targeted drug delivery; biocompatibility; biodegradability; tumor
Funding
- Spanish MINECO [PI16/00496, CTM 2017-84050-R, MAT 2015-69508-P]
- European Union FEDER Funds [PI16/00496, CTM 2017-84050-R, MAT 2015-69508-P]
- NanoBioApp Network [MINECO-17-MAT2016-81955-REDT]
- Xunta de Galicia (Centro Singular de Investigacion de Galicia -Accreditation 2016-2019)
- Xunta de Galicia [EM2014/035]
- European Union (European Regional Development Fund-ERDF)
- IDIVAL [INNVAL15/15, INNVAL17/11]
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The implementation of nanotechnology in medicine has opened new research horizons particularly in the field of therapeutic delivery. Mesoporous silica particles have emerged as biocompatible drug delivery systems with an enormous potential in the treatment of cancer among many other pathologies. In this review, we focus on the unique properties of these particles as chemotherapy delivery carriers. Here, we summarize the general characteristics of these nanomaterials - including their physicochemical properties and customizable surfaces - different stimuli that can be used to trigger targeted drug release, biocompatibility and finally, the drawbacks of these types of nanomaterials, highlighting some of the most important features of mesoporous silica nanoparticles in drug delivery.
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