Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms20092313
Keywords
neurodegenerative disease; bioactive compound; natural extract; -amyloid peptide; tau protein; clinical trial; human studies; animal studies; in vitro studies
Funding
- Laboratory for Process Engineering, Environment, Biotechnology and Energy-LEPABE - national funds through FCT/MCTES (PIDDAC) [UID/EQU/00511/2019]
- FEDER funds through COMPETE2020-Programa Operacional Competitividade e Internacionalizacao (POCI) [POCI-01-0145-FEDER-006939]
- national funds (PIDDAC) through FCT/MCTES
- Norte Portugal Regional Operational Program (NORTE 2020), under PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [LEPABE-2-ECO-INNOVATION-NORTE-01-0145-FEDER-000005]
- FCT [SFRH/BD/129312/2017]
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Alzheimer's Disease (AD) is a neurodegenerative disorder related with the increase of age and it is the main cause of dementia in the world. AD affects cognitive functions, such as memory, with an intensity that leads to several functional losses. The continuous increase of AD incidence demands for an urgent development of effective therapeutic strategies. Despite the extensive research on this disease, only a few drugs able to delay the progression of the disease are currently available. In the last years, several compounds with pharmacological activities isolated from plants, animals and microorganisms, revealed to have beneficial effects for the treatment of AD, targeting different pathological mechanisms. Thus, a wide range of natural compounds may play a relevant role in the prevention of AD and have proven to be efficient in different preclinical and clinical studies. This work aims to review the natural compounds that until this date were described as having significant benefits for this neurological disease, focusing on studies that present clinical trials.
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