Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms20092181
Keywords
miRNAs; cutaneous squamous cell carcinoma; skin cancer
Funding
- Instituto de Salud Carlos III cofinanciado con fondos FEDER [PI18/000587]
- Gerencia Regional de Salud de Castilla y Leon [GRS 1835/A/18]
- Programa de Intensificacion de la Actividad Investigadora de la Gerencia Regional de Salud de Castilla y Leon, Spain [INT/M/10/19]
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Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and it can be locally invasive and metastatic to distant sites. MicroRNAs (miRNAs or miRs) are endogenous, small, non-coding RNAs of 19-25 nucleotides in length, that are involved in regulating gene expression at a post-transcriptional level. MicroRNAs have been implicated in diverse biological functions and diseases. In cancer, miRNAs can proceed either as oncogenic miRNAs (onco-miRs) or as tumor suppressor miRNAs (oncosuppressor-miRs), depending on the pathway in which they are involved. Dysregulation of miRNA expression has been shown in most of the tumors evaluated. MiRNA dysregulation is known to be involved in the development of cutaneous squamous cell carcinoma (CSCC). In this review, we focus on the recent evidence about the role of miRNAs in the development of CSCC and in the prognosis of this form of skin cancer.
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