Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ijms20071596
Keywords
substance P; NK1R; nociception; anti-nociception; pain
Funding
- Institute of Biomedical Sciences, Academia Sinica [IBMS-CRC107-P01]
- Ministry of Science and Technology, Taiwan [MOST105-2320-B-001-018-MY3, MOST107-2319-B-001-002, MOST108-2321-B-001-005]
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Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception. Here, we review studies of SP-mediated nociception and anti-nociception in terms of peptide features, SP-modulated ion channels, and differential effector systems underlying neurokinin 1 receptors (NK1Rs) in differential cell types to elucidate the effect of SP and further our understanding of SP in anti-nociception. Most importantly, understanding the anti-nociceptive SP-NK1R pathway would provide new insights for analgesic drug development.
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