Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms20092347
Keywords
ROS; antioxidants; antioxidative enzymes; matrix; diet; fibrosis; homeostasis; hypoxia; HIF; liver; metabolic zonation; metabolism; morphogen signaling; optimization; pathology; regulatory network; sinusoid; Hepatocytes
Funding
- Academy of Finland [SA 296027]
- Jane and Aatos Erkko Foundation
- Finnish Cancer Foundation
- Sigrid Juselius Foundation
- Biocenter Oulu
- European Cooperation in Science and Technology Organization (COST Action) [BM1203/EU-ROS]
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The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not always liver, diseases impair proper metabolic zonation. Various underlying pathways, such as -catenin, hedgehog signaling, and the Hippo pathway, along with the physiologically occurring oxygen gradient, appear to be contributors. Interestingly, hypoxia and hypoxia-inducible transcription factors can orchestrate those pathways. In the current review, we connect novel findings of liver zonation in health and disease and provide a view about the dynamic interplay between these different pathways and cell-types to drive liver zonation and systemic homeostasis.
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