Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms20081904
Keywords
autophagy; Astragalus membranaceus; Astragalus membranaceus extracts; autophagy dysregulation-associated diseases
Funding
- National Natural Science Foundation of China [31671437]
- Natural Science Foundation of Guangdong Province, China [2016A030313335]
- Guangdong Provincial Key Laboratory of Construction Foundation [2017B030314030]
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Autophagy is an evolutionarily conserved self-eating' process that maintains cellular, tissue, and organismal homeostasis. New studies on autophagy, mediated by subsets of autophagy proteins, are emerging in many physiological and pathological processes. Astragalus membranaceus (AM), also named Huangqi, is one of the fundamental herbs in traditional Chinese medicine and its extracts have been proved to possess many biological activities related to autophagy, including anti-oxidation, anti-inflammation, anticancer, anti-photoaging, and improvement of cardiomyocyte function. Evidence suggests that AM extracts can have therapeutic potential in autophagy dysregulation-associated diseases because of their biological positive effects. Here we will review the literature concerning the effects of AM extracts on autophagy dysregulation-associated diseases.
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