Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 128, Issue -, Pages 885-892Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.01.211
Keywords
Acrylic acid-grafted-collagen; Self-assembly; Grafting density
Funding
- National Natural Science Foundation of China [21706201, 21676208, 21376183]
- Wuhan Morning Light Plan of Youth Science and Technology, China [2017050304010326]
- Hubei Provincial Natural Science Foundation of China [2018CFA030, 2017CFB507]
- Innovation Team Program of Hubei Province, China [T201208]
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Side chain modification of collagen provides an attractive way to enhance their structure and functions, which is highly desirable for the development of promising biomaterials. However, the impact of structural change of side chains on the intrinsic self-assembly property of collagen was always ignored. Here, a series of acrylic acid grafted-collagen (AA-g-Col) with different grafting density were prepared to explore the impact of side chain structural variation on the self-assembly of collagen. The results showed that excessive grafting density would weaken or even disappear the self-assembly property of AA-g-Col, but only affects the triple helix to a minor extent. Compared to pristine collagen, the mechanical property and cytocompatibility of AA-g-Col based matrices also deteriorated, along with the increase of grafting density. Therefore, this work contributed a new insight into the importance of grafting density for the study of modified collagen, which would be helpful for the design of optimized formulate collagen-based hybrid materials with both additional novel functions and tissue mimicking fibrillary structures. (C) 2019 Published by Elsevier B.V.
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