Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 129, Issue -, Pages 706-714Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2019.02.040
Keywords
Hedyotis diffuse polysaccharide; Metastasis; Lung adenocarcinoma A549 cells
Funding
- National Natural Science Foundation of China [8157111344]
- National Health Planning Commission Medical and Health Science and Technology Development Research Project [W2017ZWS04]
- Zhanjiang Science and Technology Planning Project [2014B01236]
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In this study we investigated the potential effects of a polysaccharide (HDP) from Hedyotis diffusa on the metastasis in human lung adenocarcinoma A549 cells. HDP (25, 50 and 100 mu g/ml) significantly suppressed the cell adhesion, invasion and migration of A549 cells in a dose dependent manner by downregulation of matrix metalloproteinase (MMP-2 and MMP-9) and upregulation of tissue inhibitors of metalloproteinase (TIMP-2 and TIMP-9). Moreover, HDP effectively downregulated the protein expressions of epithelial-mesenchymal transition (EMT) markers (N-cadherin and vimentin), and upregulated E-cadherin protein expression, which is involved in interrupting EGFR/Akt/ERK signaling pathways, as well as inhibiting COX-2 protein expression. All these results demonstrated that HDP might be a novel anti-metastatic agent for NSCLC treatment. (C) 2019 Elsevier B.V. All rights reserved.
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