Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 126, Issue -, Pages 697-716Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.12.216
Keywords
Boletus speciosus frost; Fungi polysaccharides; Structure identification; Biological activities
Funding
- Sichuan Province Science and Technology Support Program [2018JY0087, 2018NZ0055]
- Cultivate Major Projects of Sichuan Province [16CZ0018]
- Nanchong science and Technology Bureau of Sichuan Province [16YFJ0043]
- Talent Program of China West Normal University [17YC328, 17YC136, 17YC329]
- National Training Project of China West Normal University [17c039]
- Innovative Team Project of China West Normal University [CXTD2017-3]
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A new water-soluble polysaccharide named BSF-X was extracted and purified from the fruiting bodies of Boletus speciosus Frost which had a molecular weight of 141,309 Da. The structure identification results showed that BSF-X was mainly composed of beta-D-glucose and alpha-D-galactose. BSF-X had a backbone of 1, 4-linked beta-D-glucose of which branches were mainly composed of two 1, 6-linked alpha-D-galactose residue and a 4-linked beta-D-glucose at the end of the branches. Antitumor activities results showed that BSF-X could inhibit the proliferation of L929 cells in vitro and S180 tumor cells in vivo. Immunoregulatory activities results showed that BSF-X could promote the proliferation of T cells, B cells and macrophages by promoting the cells into S phase from G0/G1 phase. Polysaccharide BSF-X can also enhance the phagocytes is and cytokine secretion of macrophages. This study introduced the new polysaccharide BSF-X as a valuable source which exhibit unique antitumor and immunoregulatory properties. (C) 2018 Published by Elsevier B.V.
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