Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 127, Issue -, Pages 48-56Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.12.197
Keywords
Fucoidan compound agents; Immunomodulatory; In vitro; In vivo
Funding
- National Key R&D Program of China [2018YFD0901104]
- China Agriculture Research System [CARS 50]
- National Natural Science Foundation of China [31471610]
- National R&D Branch Center for Seaweed Processing (Dalian, China)
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Fucoidan extracted from brown algae displays diverse biological activities. In the present study, fucoidan was mixed with Chinese herb extracts, and the in vitro and in vivo immunomodulatory effects of two fucoidan compound agents were evaluated. The results showed that fucoidan from Kjellmaniella crassifolia (KF) and Undaria pinnatifida (UF) were sulfated polysaccharides, Astragalus polysaccharide (AP) was composed of alpha-D-glucose, and Codonopsis pilosula polysaccharide (CPP) was a furanose. Furthermore, fucoidan compound agents stimulated mouse macrophage RAW264.7 cell proliferation and enhanced the secretion of granulocyte-macrophage colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-alpha) in vitro. In addition, KCA (KF + AP + CPP) and UCA (UF + AP + CPP) could improve the nonspecific immunity and the specific immunity of BALB/c mice. Fucoidan compound agents also increased the secretion of GM-CSF, TNF-alpha, interleukin (IL)-4 and IL-10 in vivo. Therefore, we confirmed that fucoidan compound agents have promise for development as supplementary immunopotentiators. (C) 2019 Elsevier B.V. All rights reserved.
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