Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 112, Issue -, Pages 141-144Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2019.05.003
Keywords
Lung; Immunoregulation; Allergic asthma; CD200Fc; CD200 receptors
Categories
Funding
- Canadian Institutes of Health Research (CIHR)
- Quebec Respiratory Health Network
- Fond de Recherche du Quebec - Sante (FRQS)
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Constant exposure to foreign particles in the airways requires tight immune regulation in order to maintain sufficient anti-microbial defences, while preventing immunopathological responses that could impair gas exchange. Dysregulation of immunoregulatory pathways has been associated with asthma and allergy. This review will focus on the CD200 regulatory pathway and its role in the asthmatic cascade. CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models. Therefore, the involvement of CD200 in asthma is increasingly recognized and preclinical studies support the contention that it could constitute an additional target to alleviate asthma exacerbation and/or reduce disease severity.
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