Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 70, Issue -, Pages 428-434Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2019.03.008
Keywords
Rheumatoid arthritis; T cells; B cells; Dendritic cells; Fibroblast-like synoviocytes
Categories
Funding
- National Natural Science Foundation of China [81330081, 81603121, 81673444]
- Grants for Scientific Research of BSKY from Anhui Medical University [XJ201629]
Ask authors/readers for more resources
Rheumatoid arthritis (RA) is a chronic inflammatory synovitis-based systemic disease characterized by invasive joint inflammation and synovial hyperplasia, which can lead to arthrentasis and defunctionalization. Previous research has shown that T cells, B cells, dendritic cells (DCs), and fibroblast-like synoviocytes (FLSs) play vital roles in the regulation of RA. Both T follicular helper (Tfh) cells and helper T (Th) 17 cells play immunomodulatory roles in RA. Moreover, interleukin-23 (IL-23), and IL-17 are vital to the pathogenesis of RA. T cells behave as a hub, in that B cells, DCs, and FLSs can interact with T cells to inhibit their activation and interfere with the process of RA. T cells cooperate with B cells, DCs, and FLSs to maintain the stability of the immune system under physiological conditions. However, under pathological conditions, the balance is disrupted, and the interaction of T cells with other cells may intensify disease progression. This review focuses on the interaction of T cells with B cells, DCs, and FLSs in different tissues and organs of RA patients and animal models, and highlight that the interplay between immune cells may underline the unique function of T cells and the application prospect of targeting T cell treatment for RA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available