Journal
IMMUNITY
Volume 50, Issue 5, Pages 1149-1162Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2019.04.018
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Funding
- National Institutes of Health NIGMS [GM064709]
- NHLBI [P01HL120840]
- Odysseus Award from the FWO (Belgium)
- Mishima-Kaiun Memorial Foundation
- Kanae Foundation for the Promotion of Medical Science
- German Research Foundation (DFG) [MA 7770/1-1]
- EOS-DECODE award from the FWO (Belgium)
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Nearly every tissue in the body undergoes routine turnover of cells as part of normal healthy living. The majority of these cells undergoing turnover die via apoptosis, and then are rapidly removed by phagocytes by the process of efferocytosis that is anti-inflammatory. However, a number of pathologies have recently been linked to defective clearance of apoptotic cells. Perturbed clearance arises for many reasons, including overwhelming of the clearance machinery, disruptions at different stages of efferocytosis, and responses of phagocytes during efferocytosis, all of which can alter the homeostatic tissue environment. This review covers linkages of molecules involved in the different phases of efferocytosis to disease pathologies that can arise due to their loss or altered function.
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