Journal
IMMUNITY
Volume 50, Issue 4, Pages 851-870Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2019.03.011
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Funding
- US National Institutes of Health [R01 AI32708, AI130379, R01 AI126899, R01 AI116653]
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The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation degrees understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family members utilize shared receptors and cytokine subunits and influence the outcome of cancer, infection, and inflammatory diseases. Consequently, many facets of their biology are being therapeutically targeted. Here, we review the landmark discoveries in this field, the combinatorial biology inherent to this family, and how patient datasets have underscored the critical role of these pathways in human disease. We present significant knowledge gaps, including how similar signals from these cytokines can mediate distinct outcomes, and discuss how a better understanding of the biology of the IL-12 family provides new therapeutic opportunities.
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