Journal
GYNECOLOGICAL ENDOCRINOLOGY
Volume 35, Issue 9, Pages 737-751Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2019.1597346
Keywords
Adipokine; adiponectin; gestational diabetes; insulin resistance; insulin sensitivity; leptin
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Gestational diabetes mellitus (GDM) is a complex condition whose physiopathology to date has not been completely clarified. Two major metabolic disorders, insulin resistance and beta-cells dysfunction, play currently major role in pathogenesis of GDM. These elements are influenced by the amount of adipose tissue present before and/or during the pregnancy. Consequently, adipokines (adiponectin (APN), leptin (LPT), adipocyte fatty acid-binding protein, resistin, visfatin, omentin, vaspin, apelin, chemerin) secreted by adipose tissue, may contribute directly and/or indirectly, through the enhancement of chronic inflammation, aggravating insulin resistance and promoting GDM onset. This review aims to outline the potential physiopathological and prognostic role in GDM of adipokines, mainly APN and LPT.
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