Journal
GENOME RESEARCH
Volume 29, Issue 6, Pages 907-919Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.241372.118
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Funding
- Spanish Ministry of Economy, Industry and Competitiveness
- FEDER [SAF2016-75505-R]
- Russian Science Foundation [18-11-00171]
- Uehara Memorial Foundation
- Japan Society for the Promotion of Science (JSPS) [17H04088]
- National Bioinformatics Institute (INB), PRB2-ISCIII [PT13/0001/0044]
- Russian Science Foundation [18-11-00171] Funding Source: Russian Science Foundation
- Grants-in-Aid for Scientific Research [17H04088] Funding Source: KAKEN
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The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune response and chronic infection are poorly understood. Here, we characterized the host response to acute and chronic lymphocytic choriomeningitis virus (LCMV) infections by gene coexpression network analysis of time-resolved splenic transcriptomes. First, we found an early attenuation of inflammatory monocyte/ macrophage prior to the onset of T cell exhaustion, and second, a critical role of the XCLI-XCRI communication axis during the functional adaptation of the T cell response to the chronic infection state. These findings not only reveal an important feedback mechanism that couples T cell exhaustion with the maintenance of a lower level of effector T cell response but also suggest therapy options to better control virus levels during the chronic infection phase.
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