Journal
ANNALS OF NEUROLOGY
Volume 80, Issue 1, Pages 154-159Publisher
WILEY
DOI: 10.1002/ana.24672
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Funding
- National Institutes of Health [K23-NS089922, UL1RR024992, KL2 TR000450, P01-AG026276, P01-NS074969, P01-AG03991]
- J.P.B Foundation
- Washington University Institute of Clinical and Translational Sciences from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health [UL1TR000448]
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We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-beta. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-beta-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-beta-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid.
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